| Identification | More | [Name]
4-Fluorophenylacetone | [CAS]
459-03-0 | [Synonyms]
1-(4-FLUOROPHENYL)-2-PROPANONE
1-ACETONYL-4-FLUOROBENZENE
4'-FLUOROPHENYLACETONE
4-FLUOROPHENYLACETONE
P-FLUORO BENZYL METHYL KETONE
(P-FLUOROPHENYL)ACETONE
1-(4-Fluorophenyl)acetone
2-Propanone, 1-(4-fluorophenyl)-
P-FLUORO ENZYL METHYL KETONE
4-Fluorophenylacetone,99%
4-Fluorophenylacetone 98%
4-Fluorophenylacetone98%
1-(2-Oxopropyl)-4-fluorobenzene | [EINECS(EC#)]
207-284-7 | [Molecular Formula]
C9H9FO | [MDL Number]
MFCD00000362 | [Molecular Weight]
152.17 | [MOL File]
459-03-0.mol |
| Chemical Properties | Back Directory | [Appearance]
clear yellow liquid | [Boiling point ]
106-107 °C/18 mmHg (lit.) | [density ]
1.139 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.496(lit.)
| [Fp ]
197 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Methyl Acetate: 50 mg/ml | [form ]
clear liquid | [color ]
Light yellow to Yellow to Orange | [Specific Gravity]
1.139 | [Water Solubility ]
insoluble | [BRN ]
1936697 | [InChI]
InChI=1S/C9H9FO/c1-7(11)6-8-2-4-9(10)5-3-8/h2-5H,6H2,1H3 | [InChIKey]
ZUEKIIWSVFBTCM-UHFFFAOYSA-N | [SMILES]
C(C1=CC=C(F)C=C1)C(=O)C | [CAS DataBase Reference]
459-03-0(CAS DataBase Reference) | [NIST Chemistry Reference]
(4-Fluorophenyl)acetone(459-03-0) |
| Safety Data | Back Directory | [Hazard Codes ]
F,Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [Hazard Note ]
Flammable | [HazardClass ]
IRRITANT, FLAMMABLE | [HS Code ]
29147090 |
| Hazard Information | Back Directory | [Description]
This intermediate, also known as 4-Fluorophenylacetone, presents as a dark yellow liquid. It is known to be insoluble in water. For best results, store in a tightly closed container in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. 4-Fluorophenylacetone is incompatible with strong oxidizing agents. This chemical is a combustible liquid. | [Chemical Properties]
clear yellow liquid | [Uses]
4-Fluorophenylacetone(459-03-0) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields. It is a haloarylacetone derivative used in a study of reversed enantiopreference of an ω-transaminase by a single-point mutation. | [Application]
(4-Fluorophenyl)acetone is a phenylacetic acid derivative that inhibits the 5-HT2 receptors. It has been shown to have inhibitory activities against dopamine and serotonin by acting as an agonist at the receptor. (4-Fluorophenyl)acetone also binds to nucleophilic sites on proteins, which may lead to inhibition of protein synthesis. Brevibacterium sp. strain P7 was used as a model system and it has found that it inhibited the growth of this bacterium by binding to the enzyme RNA polymerase, preventing transcription and replication. |
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