| Identification | Back Directory | [Name]
A-317491 DISODIUM SALT | [CAS]
475205-49-3 | [Synonyms]
ABT 202
A-317491 sodium
A 317491;A317491
4-tricarboxylic acid
A-317491 DISODIUM SALT
A-317491;A 317491;A317491
(S)-5-((3-phenoxybenzyl)(1
4-tetrahydronaphthalen-1-yl)carbamoyl)benzene-1
(S)-5-((3-phenoxybenzyl)(1,2,3,4-tetrahydronaphthalen-1-yl)carbaMoyl)benzene-1,2,4-tricarboxylic acid
5-[[(3-Phenoxybenzyl)[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid
1,2,4-Benzenetricarboxylic acid, 5-[[[(3-phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-
A 317491;A317491;(S)-5-((3-PHENOXYBENZYL)(1;2;3;4-TETRAHYDRONAPHTHALEN-1-YL)CARBAMOYL)BENZENE-1;2;4-TRICARBOXYLIC ACID; SODIUM SALT HYDRATE | [Molecular Formula]
C33H27NO8 | [MOL File]
475205-49-3.mol | [Molecular Weight]
565.57 |
| Chemical Properties | Back Directory | [Boiling point ]
840.4±65.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
H2O: ~34 mg/mL
| [form ]
powder
| [pka]
2.57±0.10(Predicted) | [color ]
white
|
| Hazard Information | Back Directory | [Uses]
A-317491 is a P2X3 and P2X2/3 receptor antagonist. | [in vivo]
A-317491 (0.1-30 mg/kg; a single s.c.) dose-dependently reverses inflammatory mechanical hyperalgesia in rats[2].
A-317491 (3-30 mg/kg; a single .v.) exhibits the plasma half-life (7.38 h), clearance rate (1.83 L/h/kg), and volume of distribution (0.17 L/kg)[2]. | Animal Model: | Male adult Sprague-Dawley rats received an intraplantar injection of Freund's complete adjuvant[2] | | Dosage: | 0.1, 1, 3, 10, 30 mg/kg | | Administration: | A single s.c. | | Result: | Produced a dose-dependent reduction in mechanical hyperalgesia 1 h, 3 h and 5 h post-administration. |
| [IC 50]
P2X3 Receptor |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
|