| Identification | Back Directory | [Name]
4-hydroxy-2-Piperidinone | [CAS]
476014-76-3 | [Synonyms]
4-hydroxy-2-Piperidi
4-Hydroxy-2-piperidone
4-hydroxy-2-Piperidinone
4-Hydroxy-piperidin-2-one
2-Piperidinone, 4-hydroxy- | [Molecular Formula]
C5H9NO2 | [MDL Number]
MFCD09743648 | [MOL File]
476014-76-3.mol | [Molecular Weight]
115.13 |
| Chemical Properties | Back Directory | [Melting point ]
165-168°C | [Boiling point ]
352.3±35.0 °C(Predicted) | [density ]
1.199±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Methanol (Slightly, Sonicated) | [form ]
Solid | [pka]
14.01±0.20(Predicted) | [color ]
White to Off-White | [InChI]
InChI=1S/C5H9NO2/c7-4-1-2-6-5(8)3-4/h4,7H,1-3H2,(H,6,8) | [InChIKey]
PRCAKTIAKXMBQF-UHFFFAOYSA-N | [SMILES]
N1CCC(O)CC1=O |
| Hazard Information | Back Directory | [Uses]
4-Hydroxy-2-piperidinone is a synthetic intermediate in the synthesis of pharmaceutical goods. | [Synthesis]
Step 1) NaBH4 (1 g, 26.55 mmol) was slowly added to a solution of piperidine-2,4-dione (1 g, 8.8 mmol) in methanol (25 mL) at 0°C. The reaction mixture was stirred at room temperature overnight before the solvent was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol, 5:1, v/v) to afford 4-hydroxy-2-piperidone as a yellow solid (960 mg, 87% yield). m/z by LC-MS (ESI, positive ion mode): 138 [M + Na]+. | [References]
[1] Patent: WO2013/138210, 2013, A1. Location in patent: Paragraph 0258
[2] Patent: EP2947085, 2015, A1. Location in patent: Paragraph 0238; 0239; 0240 |
|
|