| Identification | Back Directory | [Name]
Geldanamycin, 17-[(6-aminohexyl)amino]-17-demethoxy- | [CAS]
485395-71-9 | [Synonyms]
Aminohexylgeldanamycin
Geldanamycin, 17-[(6-aminohexyl)amino]-17-demethoxy- | [Molecular Formula]
C34H52N4O8 | [MDL Number]
MFCD34167487 | [MOL File]
485395-71-9.mol | [Molecular Weight]
644.81 |
| Chemical Properties | Back Directory | [Boiling point ]
847.9±65.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C, protect from light | [solubility ]
DMSO: 200 mg/mL (310.17 mM) | [form ]
Solid | [pka]
8.63±0.70(Predicted) | [color ]
Purple to black |
| Hazard Information | Back Directory | [Uses]
Aminohexylgeldanamycin (AHGDM), a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin shows antiangiogenic and antitumor activities[1]. | [IC 50]
HSP90 | [storage]
-20°C, protect from light | [References]
[1] Greish K, et al. Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy. J Control Release. 2011;151(3):263-270. DOI:10.1016/j.jconrel.2010.12.015
[2] Larson N, et al. HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer. Pharm Res. 2010;27(12):2683-2693. DOI:10.1007/s11095-010-0267-7 |
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