| Identification | Back Directory | [Name]
Boc-NH-ethyl-SS-propionic acid | [CAS]
485800-27-9 | [Synonyms]
Boc-NH-ethyl-SS-propionic acid
3-((2-(TERT-BUTOXYCARBONYLAMINO)ETHYL)DISULFANYL)PROPANOIC ACID
Propanoic acid, 3-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]dithio]- | [Molecular Formula]
C10H19NO4S2 | [MDL Number]
MFCD19443373 | [MOL File]
485800-27-9.mol | [Molecular Weight]
281.39 |
| Chemical Properties | Back Directory | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Boc-NH-ethyl-SS-propionic acid is a cleavable crboxylic acid linker. The terminal carboxylic acid group can be reacted with a primary amine in the presence of activators such as EDC and HATU to form stable amide bonds. The boc protecting group can be removed under acidic conditions to release the free amine for further reaction. | [Uses]
Boc-NH-ethyl-SS-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [IC 50]
Disulfide Cleavable Linker; Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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