| Identification | Back Directory | [Name]
FRAXINOL | [CAS]
486-28-2 | [Synonyms]
Fraxil
FRAXINOL
5,7-Dimethoxy-6-hydroxycoumarin
6-Hydroxy-5,7-dimethoxycoumarin
6-Hydroxy-5,7-dimethoxy-chromen-2-one
6-Hydroxy-5,7-dimethoxy-2H-1-benzopyran-2-one | [Molecular Formula]
C11H10O5 | [MDL Number]
MFCD08693526 | [MOL File]
486-28-2.mol | [Molecular Weight]
222.19 |
| Chemical Properties | Back Directory | [Melting point ]
170-172℃ | [Boiling point ]
449.7±45.0 °C(Predicted) | [density ]
1.358 | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO and methanol; | [form ]
powder | [pka]
8.95±0.20(Predicted) | [color ]
White-yellowish | [Water Solubility ]
slightly soluble in water | [Major Application]
food and beverages | [InChI]
1S/C11H10O5/c1-14-8-5-7-6(3-4-9(12)16-7)11(15-2)10(8)13/h3-5,13H,1-2H3 | [InChIKey]
PBPNOAHYDPHKFH-UHFFFAOYSA-N | [SMILES]
[o]1c2c(c(c(c(c2)OC)O)OC)cc[c]1=O | [CAS DataBase Reference]
486-28-2 |
| Hazard Information | Back Directory | [Description]
Fraxinol is a coumarin originally isolated from Ash tree bark.1 It inhibits growth of GLC-4 small cell lung carcinoma and COLO 320 colorectal cancer cells (IC50s = 193 and 165 μM, respectively).2 Fraxinol potentiates barbiturate-induced sleep in rats and rabbits.3 | [Chemical Properties]
White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the fraxinus chinensis tree. | [Uses]
Fraxinol is isolated from Lobelia chinensis[1]. | [References]
[1] Wei J, et al. In vitro inhibitory effects of Friedelin on human liver cytochrome P450 enzymes. Pharm Biol. 2018 Dec;56(1):363-367. DOI:10.1080/13880209.2018.1491999 |
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