| Identification | More | [Name]
Ononin | [CAS]
486-62-4 | [Synonyms]
4',7-DIHYDROXY-7-O-GLUCOSYLISOFLAVONE
4'-METHOXYISOFLAVONE-7-O-BETA-D-GLUCOPYRANOSIDE
FORMONONETIN-7-O-BETA-D-GLUCOPYRANOSIDE
FORMONONETIN-7-O-GLUCOSIDE
GLUCOSYL-7-O-FORMONONETIN
ONONIN
Fomononetin
formononetin-7-o-β-d-glucopyranoside
ONONIN WITH HPLC
Ononin，Formononetin-7-glucoside
4'-Methoxy-7-(β-D-glucopyranosyloxy)isoflavone
7-(β-D-Glucopyranosyloxy)-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one | [Molecular Formula]
C22H22O9 | [MDL Number]
MFCD00017464 | [Molecular Weight]
430.4 | [MOL File]
486-62-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
216°C | [Boiling point ]
697.8±55.0 °C(Predicted) | [density ]
1.482±0.06 g/cm3(Predicted) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly) | [form ]
Solid | [pka]
12.71±0.70(Predicted) | [color ]
Off-White | [λmax]
302nm(MeOH)(lit.) | [BRN ]
63067 | [Stability:]
Hygroscopic | [InChIKey]
MGJLSBDCWOSMHL-JQQDRUSQSA-N | [SMILES]
COc1ccc(cc1)C2=COc3cc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)ccc3C2=O | [LogP]
0.630 (est) | [CAS DataBase Reference]
486-62-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3 | [HS Code ]
2938900000 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Astragalus and Licorice. | [Uses]
Ononin is an isoflavone compound from Glycyrrhiza uralensis is the 7-O-glucoside of Formononetin (F693200), an isoflavone found as one of the main plant estrogens in animal feed. When metabolized in the rumen this compound transforms into a potent estrogen. | [Definition]
ChEBI: A methoxyisoflavone that is formononetin attached to a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. | [Biological Activity]
A isoflavone glucoside found in soybeankudzuand the Chinese medicinal herbRadix astragali (RA). RA is a supplement taken to improve "energy." It may act by inducing erythropoietin expression. | [in vivo]
Ononin (30 mg/kg, p.o., 12 days) shows neuroprotective effects against aluminium chloride-induced Alzheimer’s disease in rats[4].
Ononin (10-50 mg/kg, p.o., once a day for 60?days) mitigates Streptozotocin (HY-13753)-induced diabetic nephropathy in rats via alleviating oxidative stress and inflammatory markers[5].
Ononin (30-60 mg/kg/day, gavage, 8 weeks) alleviates endoplasmic reticulum stress in Doxorubicin (HY-15142A)-induced cardiotoxicity in rats by activating SIRT3[6].
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