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487001-04-7

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487001-04-7 Structure

487001-04-7 Structure

Identification	Back Directory
[Name] UC-857993
[CAS] 487001-04-7
[Synonyms] UC-857993 Benzo[ij]dicyclopenta[b,g]quinolizine-2-carboxylic acid, 7-(2-chlorophenyl)-3b,6,6a,7,9,9a,10,12a-octahydro-
[Molecular Formula] C25H22ClNO2
[MOL File] 487001-04-7.mol
[Molecular Weight] 403.9

Chemical Properties	Back Directory
[Boiling point ] 549.1±50.0 °C(Predicted)
[density ] 1.40±0.1 g/cm3(Predicted)
[pka] 4.90±0.40(Predicted)

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[Uses] UC-857993 is a selective SOS1-Ras inhibitor (Kd=14.7 μM, His6-SOS1cat), suppressing catalytic activity. UC-857993 also inhibits ERK and Ras activation, suppresses the growth of mouse embryonic fibroblasts (MEFs)[1].
[References] [1] Evelyn CR, et al. Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. J Biol Chem. 2015 May 15;290(20):12879-98. DOI:10.1074/jbc.M114.634493

487001-04-7 suppliers list

Company Name:	Nanjing Shizhou Biology Technology Co.,Ltd
Telephone:	025-85560043 15850508050
Website:	http://www.synzest.com

Company Name:	TargetMol Chemicals Inc.
Telephone:	15002134094
Website:	https://www.targetmol.cn/

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