| Identification | Back Directory | [Name]
1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL | [CAS]
488-41-5 | [Synonyms]
r54
myebrol
nsc-94100
NSC 94110
nci-c04762
mieobromol
myelobromol
dibromannit
Mielobromol
mitobronitol
Dibrommannit
Dibromannitol
dibromomannitol
d-dibromomannitol
1,6-dibromomannitol
1,6-Dibromo-D-mannitol
1,6-Dibromo-1,6-dideoxymannitol
6-dibromo-1,6-dideoxy-d-mannito
1,6-dibrom-1,6-didesoxy-d-mannit
1,6-dibromo-1,6-d-didesoxymannitol
1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL
1,6-Dideoxy-1,6-dibromo-D-mannitol
MANNITOL,1,6-DIBROMO-1,6-DIDEOXY-,D-
D-Mannitol, 1,6-dibromo-1,6-dideoxy-
D-Mannitol, 1,6-dibromo-1,6-dideoxy- (9CI)
Mannitol, 1,6-dibromo-1,6-dideoxy-, D- (8CI)
1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL USP/EP/BP
(2S,3S,4S,5S)-1,6-dibromohexane-2,3,4,5-tetrol
(2S,3S,4S,5S)-1,6-Dibromohexane-2,3,4,5-tetraol | [EINECS(EC#)]
207-676-8 | [Molecular Formula]
C6H12Br2O4 | [MDL Number]
MFCD00045046 | [MOL File]
488-41-5.mol | [Molecular Weight]
307.97 |
| Chemical Properties | Back Directory | [Melting point ]
176-178° | [Boiling point ]
511.2±50.0 °C(Predicted) | [density ]
1.8987 (rough estimate) | [refractive index ]
1.4840 (estimate) | [storage temp. ]
−20°C | [pka]
12.61±0.20(Predicted) | [InChI]
InChI=1S/C6H12Br2O4/c7-1-3(9)5(11)6(12)4(10)2-8/h3-6,9-12H,1-2H2/t3-,4-,5-,6-/m1/s1 | [InChIKey]
VFKZTMPDYBFSTM-KVTDHHQDSA-N | [SMILES]
C(Br)[C@H]([C@H]([C@@H]([C@@H](CBr)O)O)O)O | [EPA Substance Registry System]
Mitobronitol (488-41-5) |
| Hazard Information | Back Directory | [Originator]
Myelobromol,Hormonchemie,W. Germany,1967 | [Uses]
Antineoplastic. | [Definition]
ChEBI: Mitobronitol is an alcohol and an organobromine compound. | [Manufacturing Process]
750 g D-mannitol are dissolved in 4,000 ml of a 48% aqueous hydrogenbromide solution, whereupon the solution thus obtained is saturated at 0°Cwith gaseous hydrogen bromide until a HBr content of 69 to 70% is achieved.The reaction mixture is heated for 6 hours at 60°C in an autoclave, is thendecolorized with charcoal, extracted with 1 liter chloroform twice and dilutedwith 7 liters of water. The pH value of the solution is adjusted by means ofsodium bicarbonate to1 to 2. The crystals precipitated after cooling for a dayare filtered and washed with water until free from acid. 250 g crude 1,6-dibromo-1,6-didesoxy-D-mannitol are obtained. MP 176° to 178°C. Analysis:Br % = 52 (calc.: 51.9).
250 g of the crude DBM are dissolved in 2.5 liters of hot methanol and ondecolorizing and filtration 2.5 liters of dichloroethane are added. 220 g ofcrystalline DBM are obtained. MP 178°C. Br % = 51.9. | [Therapeutic Function]
Cancer chemotherapy | [General Description]
White powder. | [Air & Water Reactions]
Insoluble in water. | [Reactivity Profile]
A halogenated alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides. | [Fire Hazard]
Flash point data for 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL are not available, but 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL is probably combustible. |
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