489446-42-6

Di-tert-butyl dicarbonate (3.5 g, 16 mmol) and triethylamine (13 mL, 9.4 mmol) were added to a stirred solution of 4-aminomethylphenylboronic acid (3 g, 16 mmol) in tetrahydrofuran (100 mL). The reaction was stirred under reflux for 1 hour, then the solvent was evaporated and the residue was partitioned between water and ethyl acetate. The organic phase was concentrated under reduced pressure to give 4-(N-BOC-aminomethyl)phenylboronic acid (2.67 g, 10.6 mmol) as a white solid.