| Identification | More | [Name]
N-Methylolacrylamide | [CAS]
924-42-5 | [Synonyms]
METHYLOLACRYLAMIDE
n-(hydroxymethyl)-2-propenamide
N-(HYDROXYMETHYL)ACRYLAMIDE
N-METHYLOLACRYLAMIDE
2-Propenamide,N-(hydroxymethyl)-
Acrylamide, N-(hydroxymethyl)-
Monomethylolacrylamide
n-(hydroxymethyl)-2-propenamid
n-(hydroxymethyl)-acrylamid
NCI-C60333
NM-AMD
N-Methanolacrylamide
N-Methyloacrylamide
n-methylolacrylamide(48%inwater)
Uramine T 80
uraminet80
Yuramin T 80
Methylolacrylamidesolution
N-MAN
N-(HYDROXYMETHYL)ACRYLAMIDE SOLUTION, ST AB., ~48% IN H2O | [EINECS(EC#)]
213-103-2 | [Molecular Formula]
C4H7NO2 | [MDL Number]
MFCD00004597 | [Molecular Weight]
101.1 | [MOL File]
924-42-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
74-75°C | [Boiling point ]
277°C(lit.) | [density ]
1.082 g/mL at 20 °C
| [vapor pressure ]
31 hPa (25 °C) | [refractive index ]
n20/D 1.413
| [Fp ]
100°C | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
13.25±0.10(Predicted) | [color ]
White to Off-White | [Specific Gravity]
1.074 | [PH]
6.0-7.0 (H2O, 20°C) | [Water Solubility ]
<0.1 g/100 mL at 20.5 ºC | [BRN ]
506646 | [Stability:]
Light Sensitive, Moisture Sensitive | [InChI]
1S/C4H7NO2/c1-2-4(7)5-3-6/h2,6H,1,3H2,(H,5,7) | [InChIKey]
CNCOEDDPFOAUMB-UHFFFAOYSA-N | [SMILES]
OCNC(=O)C=C | [LogP]
-1.81 at 20℃ and pH7 | [CAS DataBase Reference]
924-42-5(CAS DataBase Reference) | [IARC]
3 (Vol. 60) 1994 | [NIST Chemistry Reference]
2-Propenamide, n-(hydroxymethyl)-(924-42-5) | [EPA Substance Registry System]
924-42-5(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
2810 | [WGK Germany ]
3
| [RTECS ]
AS3600000 | [TSCA ]
TSCA listed | [HazardClass ]
4.1 | [PackingGroup ]
III | [HS Code ]
29241990 | [Storage Class]
6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Carc. 1B
Muta. 1B
Repr. 2
Skin Sens. 1
STOT RE 1
STOT RE 2 Oral | [Hazardous Substances Data]
924-42-5(Hazardous Substances Data) |
| Hazard Information | Back Directory | [General Description]
A colorless or yellow aqueous solution. | [Reactivity Profile]
N-METHYLOLACRYLAMIDE(924-42-5) may be sensitive to prolonged exposure to light. Polymerization and generation of heat and flames may occur on exposure to to heat or contaminants. Incompatible with strong oxidizers. | [Air & Water Reactions]
Soluble in water. | [Fire Hazard]
Literature sources indicate that this chemical is nonflammable. | [Chemical Properties]
White solid | [Uses]
N-(Hydroxymethyl)acrylamide can be used as: - A monomer in the development of polymer gel dosimeters specifically designed for radiation therapy applications. The incorporation of NHMA enhances the sensitivity of the dosimeter to radiation doses.
- A monomer in the development of thermo-responsive polymeric gates, which exhibits thermo-responsive behavior. The incorporation of NHMA enhances the overall properties of the polymer, allowing for better control over the release mechanisms in response to temperature changes.
- A key monomer in the synthesis of double-hydrophilic and amphiphilic block glycopolymers, contributing to their self-assembly properties, biocompatibility, and functionalization potential. These characteristics make NHMA-based glycopolymers valuable for various biomedical applications, including drug delivery systems, biosensors, and tissue engineering.
| [Definition]
ChEBI: N-Methylolacrylamide is a secondary carboxamide. | [Synthesis]
(1), the acrylamide is added to the reaction kettle containing solvent acetone, the polymerization blocking agent is added, and the temperature is raised to 42～45℃;
(2), adding catalyst sodium methanol, adjusting the pH value in the reaction so |
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