| Identification | Back Directory | [Name]
PMED-1 | [CAS]
491828-75-2 | [Synonyms]
PMED-1
Cyclopropanecarboxamide, N-[1-[(4-fluorophenyl)methyl]-1H-pyrazol-4-yl]-2-phenyl- | [Molecular Formula]
C20H18FN3O | [MOL File]
491828-75-2.mol | [Molecular Weight]
335.38 |
| Chemical Properties | Back Directory | [Boiling point ]
585.457±50.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.286±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
14.248±0.40(predicted) |
| Hazard Information | Back Directory | [Uses]
PMED-1 is a β-catenin inhibitor that significantly reduces β-catenin activity in hepatoblastoma cells and various HCC cells, with an IC50 value ranging from 4.87 to 32 μM. PMED-1 affects Wnt signaling by decreasing the interaction between β-catenin and CREB binding protein, thereby inhibiting cell proliferation. PMED-1 has potential applications in cancer research[1]. | [References]
[1] Delgado ER, et al. Identification and characterization of a novel small-molecule inhibitor of β-catenin signaling. Am J Pathol. 2014 Jul;184(7):2111-22. DOI:10.1016/j.ajpath.2014.04.002 |
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