| Identification | Back Directory | [Name]
MAY-262611 | [CAS]
1123231-07-1 | [Synonyms]
DKK1
CS-1296
WAY-262611
MAY-262611
Wnt/β-catenin
WAY262611; WAY 262611
Human DKK1 Protein, His Tag
Recombinant Mouse Dkk-1 Protein, 8*His Tag
Recombinant Human DKK-1/DKK1 Protein, 8* His Tag
1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine
1-{1-[4-(2-Naphthyl)-2-pyrimidinyl]-4-piperidinyl}methanamine
4-PiperidineMethanaMine, 1-[4-(2-naphthalenyl)-2-pyriMidinyl]-
1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine MAY-262611 | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C20H22N4 | [MDL Number]
MFCD20527803 | [MOL File]
1123231-07-1.mol | [Molecular Weight]
318.42 |
| Chemical Properties | Back Directory | [Boiling point ]
544.8±42.0 °C(Predicted) | [density ]
1.169±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml | [form ]
Powder | [pka]
10.13±0.29(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
WAY-262611 is a Wnt/β-Catenin agonist that increases bone formation rate with an EC50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also a Dkk1 inhibitor[1]. | [Definition]
ChEBI: [1-[4-(2-naphthalenyl)-2-pyrimidinyl]-4-piperidinyl]methanamine is a member of naphthalenes. | [in vivo]
WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wntβ-catenin pathway and most likely through inhibition of Dkk-1[1]. | [storage]
Store at -20°C | [References]
[1] Pelletier JC, et al. (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate. J Med Chem. 2009 Nov 26;52(22):6962-5. DOI:10.1021/jm9014197
[2] L Enochson, et al. GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition. Osteoarthritis Cartilage. 2014 Apr;22(4):566-77. DOI:10.1016/j.joca.2014.02.004 |
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