| Identification | More | [Name]
2,3-Dihydrobenzofuran | [CAS]
496-16-2 | [Synonyms]
2,3-DIHYDROBENZO[B]FURAN
2,3-DIHYDROBENZOFURAN
BUTTPARK 44\01-23
COUMARAN
2,3-Dihydro-1-benzofuran
2,3-dihydro-benzofura
Coumaran (2,3-dihydrobenzofuran)
Dihydrobenzofuran
Dihydrocoumarone
Kumaran
Coumaran~2,3-Dihydro-2,3-benzofuran
2,3 Dihydro bezofuran
2,3-Dihydrobenzofurane
Cumaran
2,3-dihydro-2,3-benzofuran
Benzofuran,2,3-dihydro-
2,3-DIHYDROBENZOFURAN,98%
2,3-Dihydrobenzobüfuran, 98%
Benzodihydrofuran | [EINECS(EC#)]
207-817-3 | [Molecular Formula]
C8H8O | [MDL Number]
MFCD00005855 | [Molecular Weight]
120.15 | [MOL File]
496-16-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to light yellow liqui | [Melting point ]
-21°C | [Boiling point ]
188-189 °C (lit.) | [density ]
1.065 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.549(lit.)
| [Fp ]
152 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
alcohol: soluble | [form ]
clear liquid | [color ]
Colorless to Yellow to Green | [Specific Gravity]
1.065 | [Detection Methods]
GC,NMR | [Merck ]
14,2559 | [BRN ]
111928 | [InChI]
1S/C8H8O/c1-2-4-8-7(3-1)5-6-9-8/h1-4H,5-6H2 | [InChIKey]
HBEDSQVIWPRPAY-UHFFFAOYSA-N | [SMILES]
C1Cc2ccccc2O1 | [LogP]
2.140 | [CAS DataBase Reference]
496-16-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzofuran, 2,3-dihydro-(496-16-2) | [EPA Substance Registry System]
496-16-2(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H227 | [Precautionary statements ]
P210-P280-P370+P378-P403+P235-P501-P210e-P280a-P370+P378a-P501a | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [TSCA ]
Yes | [REACH Registrations]
Inactive | [HS Code ]
29329995 | [Storage Class]
10 - Combustible liquids |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Ethylidenecyclohexane-->2-Chlorostyrene-->2-Chlorophenethylalcohol-->Benzofuran-->2-Chlorotoluene | [Preparation Products]
1-Benzofuran-5-carbaldehyde-->2,3-Dihydrobenzo[b]furan-5-carbaldehyde-->2,3-Dihydrobenzofuran-7-carboxylic acid-->2,3-Dihydrobenzofuran-5-boronic acid-->5-(Aminomethyl)-2,3-dihydrobenzo[b]furan-->5-Acetyl-2,3-dihydrobenzo(b)furan-->1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one-->2,3-Dihydro-1-benzofuran-5-ylmethanol-->2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine-->2,3-Dihydro-1-benzofuran-5-propanoic acid-->Darifenacin-->5-Bromo-2,3-dihydro-1-benzofuran |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to light yellow liqui | [Uses]
2,3-dihydrobenzofuran is widely used in the synthesis of tricyclic compounds and is also an intermediate raw material for the synthesis of some important drugs. It is used in the synthesis of antitumor agents benzofuran sulfonylureas, HIV protease inhibitor amino acid hydroxyethylenesulfonyl, matrix metalloproteinase inhibitor aryl sulfinyl isoxime hydroxamic acid, etc. | [Definition]
ChEBI: A member of the class of 1-benzofurans that is the 2,3-dihydroderivative of benzofuran. | [General Description]
Biotransformation of 2,3-dihydrobenzofuran using intact cells of Pseudomonas putida UV4 has been investigated. 2,3-Dihydrobenzofuran is the intermediate formed during catalytic hydrodeoxygenation of benzofuran. | [Synthesis]
Step 1: Synthesis of 2-phenoxyethanol
Add 200 ml of anhydrous ethanol to a 10000 m L three-necked round-bottomed flask, dissolve sodium metal (23 g) in it, then add phenol (94 g, 900 mL), 2-chloroethanol (700 mL) , respectively, and heat and refl |
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