| Identification | Back Directory | [Name]
1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone | [CAS]
50405-58-8 | [Synonyms]
TC-E 5008
TC E 5008,TCE 5008
6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one
1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone
2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(phenylmethyl)- | [Molecular Formula]
C13H13NO2 | [MDL Number]
MFCD30290154 | [MOL File]
50405-58-8.mol | [Molecular Weight]
215.25 |
| Hazard Information | Back Directory | [Uses]
TC-E 5008 is a cancer-assocaited mutant isocitrate dehydrogenase inhibitor, which was found to be permeable through the blood-brain barrier. | [Definition]
ChEBI: SYC-435 is a cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and benzyl groups, respectively. It is a potent inhibitor of mutant isocitrate dehydrogenase 1 (Ki values of 190 nM against R132H mutant and 120 nM against R132C mutant). It has a role as an EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor and an antineoplastic agent. It is a member of benzenes, a pyridone and a cyclic hydroxamic acid. | [IC 50]
R132H IDH1: 190 nM (Ki); R132C IDH1: 120 nM (Ki); WT IDH1: 12.3 μM (Ki) |
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