| Identification | Back Directory | [Name]
(+)METHAMPHETAMINE HYDROCHLORIDE | [CAS]
51-57-0 | [Synonyms]
adipex
deofed
destim
dextim
desoxyn
dexoval
syndrox
doxyfed
gerovit
isophen
drinalfa
efroxine
tonedron
pervitin
philopon
desyphed
desoxyfed
eufodrinal
methylisomyn
soxysympamine
(+)-Methamphetamine
norodinhydrochloride
D-DESOXYEPHEDRINE HCL
D-Methamphetamine HCl
(+)-methamphetamineHCl
methamphetaminiumchloride
metamfetaminehydrochloride
TWXDDNPPQUTEOV-FVGYRXGTSA-N
(+)-Methaphetamine chloride
(+)-methamphetaminechloride
Deoxyephedrine hydrochloride
d-deoxyephedrinehydrochloride
d-methamphetaminehydrochloride
D-METHAMPHETAMINE CHLORHYDRATE
(+)-Metamfetamine hydrochloride
D-DESOXYEPHEDRINE HYDROCHLORIDE
METHYLAMPHETAMINE HYDROCHLORIDE
(+)METHAMPHETAMINE HYDROCHLORIDE
n-methylamphetaminehydrochloride
(+)-Metamphetamine hydrochloride
(+)-Methaphetamine hydrochloride
d-methylamphetaminehydrochloride
S-(+)-Methamphetamine Hydrochloride
(+)-Methamphetamine (hydrochloride)
(+)-MethaMphetaMine Hydrochloride (CII)
(+)METHAMPHETAMINE HYDROCHLORIDE--DEA &
(+)-Methamphetamine (hydrochloride) (CRM)
(+)-methamphetamine hydrochloride solution
d-N,α-Dimethylphenethylamine hydrochloride
plus-methamphetamine hcl*methanol solution
Methamphetamine Hydrochloride CII (125 mg)
PHENETHYLAMINE,N,ALPHA-DIMETHYL-,HYDROCHLORIDE
D-N,ALPHA-DIMETHYLPHENETHYLAMINE HYDROCHLORIDE
(S)-N,a-dimethylbenzeneethanaminehydrochloride
(+)-2-Methylamino-2-phenylpropane hydrochloride
(+)methamphetamine hydrochloride--dea*schedule ii
d-n-methyl-beta-phenylisopropylaminehydrochloride
Rabbit Anti-Methamphetamine/HRP Conjugated antibody
n,alpha-dimethyl-,hydrochloride,(s)-benzeneethanamin
n,alpha-dimethyl-,hydrochloride,(s)-(+)-phenethylamin
(+)-METHAMPHETAMINE HYDROCHLORIDE ADRENE RGIC AGONIST
d-Methamphetamine.HCl, 1mg/ml in Methanol (as free base)
BenzeneethanaMine, N,a-diMethyl-, hydrochloride (1:1),(aS)-
Benzeneethanamine, N,.alpha.-dimethyl-, hydrochloride, (.alpha.S)-
Methamphetamine Hydrochloride CII(Secondary Standards traceble to USP)
Methamphetamine Hydrochloride ((S)-(+)-Methamphetamine Hydrochloride) 0.1 mg/ml in Methanol (as free base)
Methamphetamine Hydrochloride ((S)-(+)-Methamphetamine Hydrochloride) 1.0 mg/ml in Methanol (as free base)
d-Desoxyephedrine hydrochloride, d-N,α-Dimethylphenethylamine hydrochloride, Methylamphetamine hydrochloride | [EINECS(EC#)]
200-106-9 | [Molecular Formula]
C10H16ClN | [MDL Number]
MFCD00056130 | [MOL File]
51-57-0.mol | [Molecular Weight]
185.69 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
A CNS stimulant. Anorexic. In attention deficit disorder with hyperactivity.
Controlled substance (stimulant). | [Definition]
ChEBI: A hydrochloride having methamphetamine as the base component. | [Description]
(+)-Methamphetamine (Item No. 13997) is an analytical reference material categorized as an amphetamine. It is the more physiologically active isomer of (±)-methamphetamine and is both neurotoxic and frequently abused. Methamphetamine is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications. | [Originator]
Desoxyn ,Abbott Laboratories | [Manufacturing Process]
2 Methods of prepearing of methamphetamine:
1. (-)-Ephedrin was reduced by hydrogenesation with hydrogen in the presence of Pt-C catalyst to give the (+)-N-α-dimethylphenethylamine (methamphetamine), melting point 172°-174°C.
2. Methamphetamine was obtained by the methylation of
phenylisopropylamine.
To give methamphetamine hydrochloride the base methamphetamine was
treated by eqimolar quantity of hydrochloric acid. | [Therapeutic Function]
Sympathomimetic, Central stimulant | [General Description]
Methamphetamine, (+)-1-phenyl-2-methylaminopropanehydrochloride desoxyephedrine hydrochloride (Desoxyn), isthe N-methyl analog of dextroamphetamine. It has moremarked central and less peripheral action than dextroamphetamine.It has a very high abuse potential, and by the intravenousroute, its salts are known as “speed.” The overallabuse problem presented by the drug is a national disaster.Medicinally acceptable uses of methamphetamine are analogousto those of dextroamphetamine. | [Biochem/physiol Actions]
Sympathomimetic with more potent central effects than amphetamine. It is transported into terminals via the monoamine transporters and induces release of dopamine, norepinephrine, epinephrine, and serotonin. Dopamine release is important for the addictive properties of methamphetamine while norepinephrine and epinephrine release are important for the cardiovascular effects. Serotonin neurotoxin. | [References]
[1] DAVID JIROVSKY . Methamphetamine — properties and analytical methods of enantiomer determination[J]. Forensic science international, 1998, 96 1: Pages 61-70. DOI: 10.1016/s0379-0738(98)00104-2
[2] SHAOBIN YU. Recent advances in methamphetamine neurotoxicity mechanisms and its molecular pathophysiology.[J]. Behavioural Neurology, 2015, 2015: 103969. DOI: 10.1155/2015/103969
[3] RICHARD B ROTHMAN. In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates.[J]. Journal of Pharmacology and Experimental Therapeutics, 2003, 307 1: 138-145. DOI: 10.1124/jpet.103.053975
[4] JUSTIN K ICHIDA. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.[J]. Cell stem cell, 2009, 5 5: 491-503. DOI: 10.1016/j.stem.2009.09.012 |
| Safety Data | Back Directory | [Hazard Codes ]
T,F | [Risk Statements ]
25-39/23/24/25-23/24/25-11 | [Safety Statements ]
45-36/37-16 | [RIDADR ]
3249 | [WGK Germany ]
2 | [RTECS ]
SH5455000 | [TSCA ]
TSCA listed | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
2939710000 | [Safety Profile]
Poison by ingestion,
subcutaneous, intravenous, and
intraperitoneal routes. An experimental
teratogen. Experimental reproductive
effects. Questionable carcinogen with
experimental neoplastigenic data. When heated to decomposition it emits toxic
fumes of NOx and HCl. See also
BENZEDRINE and various amphetamines. | [Toxicity]
LD50 i.p. in mice: 70 mg/kg (Lands) |
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