| Identification | More | [Name]
(4-AMINO-PHENYL)-MORPHOLIN-4-YL-METHANONE | [CAS]
51207-86-4 | [Synonyms]
AKOS B000462
N-(p-AMinoben
BUTTPARK 19\02-43
ART-CHEM-BB B000462
CHEMBRDG-BB 3000462
TIMTEC-BB SBB000456
p-AMinobenzoylMorpholine
4-(4-AMinobenzoyl)Morpholine
4-(p-AMinobenzoyl)Morpholine
4-AMINOBENZOIC ACID, MORPHOLIDE
Morpholine, 4-(4-aminobenzoyl)-
4-(morpholine-4-carbonyl)aniline
4-(4-Morpholinylcarbonyl)aniline
(4-AMINOPHENYL)(MORPHOLINO)METHANONE
4-(MORPHOLIN-4-YLCARBONYL)PHENYLAMINE
Methanone, (4-aminophenyl)(4-morpholyl)-
(4-AMINO-PHENYL)-MORPHOLIN-4-YL-METHANONE
Methanone, (4-aminophenyl)-4-morpholinyl-
1-(4-AMinophenyl)-1-Morpholin-4-ylMethanone
4-(morpholin-4-ylcarbonyl)aniline(SALTDATA: FREE)
4-(4-Aminobenzoyl)morpholine Other Name (4-Aminophenyl)(4-morpholinyl)methanone | [Molecular Formula]
C11H14N2O2 | [MDL Number]
MFCD00158788 | [Molecular Weight]
206.24 | [MOL File]
51207-86-4.mol |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H332-H335 | [Precautionary statements ]
P261-P280-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [HazardClass ]
IRRITANT | [HS Code ]
2934999090 |
| Hazard Information | Back Directory | [Uses]
(4-Amino-Phenyl)-Morpholin-4-yl-Methanone is an morpholine derivative used in the preparation of tyrosine kinase inhibitors and other biologically active agents.
| [Synthesis]
Step - (ii): Synthesis of (4-aminophenyl)(morpholino)methanone: Intermediate-8a (8.5 g, 35.9 mmol) was dissolved in methanol (200 mL), 10% Pd/C (850 mg) was added and stirred for 4 hours at room temperature under H2 atmosphere. After completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and washed with excess methanol. The filtrate was concentrated in vacuum to afford the target product (7.0 g, 94.53%) as a light yellow solid.1H-NMR (400 MHz, DMSO-d6) δ: 7.12 (d, 2H, J = 8.4 Hz), 6.55 (d, 2H, J = 8.0 Hz), 5.5 (bs, 2H), 3.66-3.28 (m, 8H); MS (ES) m /z 207 (M + 1). | [References]
[1] Green Chemistry, 2018, vol. 20, # 1, p. 130 - 135
[2] Organic Letters, 2017, vol. 19, # 1, p. 194 - 197
[3] ACS Catalysis, 2015, vol. 5, # 3, p. 1526 - 1529
[4] Patent: WO2014/125410, 2014, A1. Location in patent: Page/Page column 26; 27
[5] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 9, p. 1615 - 1620 |
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