| Identification | More | [Name]
Pyridine-2-carboximidamide hydrochloride | [CAS]
51285-26-8 | [Synonyms]
2-AMIDINOPYRIDINE HYDROCHLORIDE
2-AMIDINOPYRIDINIUM CHLORIDE
2-AMIDINOPYRIDINIUM HYDROCHLORIDE HYDRATE
2-PYRIDINECARBOXIMIDAMIDE, HYDROCHLORIDE
BUTTPARK 32\03-54
PYRIDINE-2-CARBOXIMIDAMIDE HYDROCHLORIDE
Pyridin-2-ylcarboximidamide hydrochloride
2-AmidinopyridiniumHClhydrate
2-Amidinopyridinium hydrochloride
2-Amidinopyridine
Pyridine-2-carboxamidine Hydrochloride
Picolinimidamidehydrochloride | [EINECS(EC#)]
676-441-3 | [Molecular Formula]
C6H8ClN3 | [MDL Number]
MFCD00052271 | [Molecular Weight]
157.6 | [MOL File]
51285-26-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
150-152°C | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
crystals | [color ]
Off-white | [Sensitive ]
Hygroscopic | [BRN ]
3562671 | [InChI]
InChI=1S/C6H7N3.ClH/c7-6(8)5-3-1-2-4-9-5;/h1-4H,(H3,7,8);1H | [InChIKey]
GMHCEDDZKAYPLB-UHFFFAOYSA-N | [SMILES]
C(C1N=CC=CC=1)(N)=N.Cl | [CAS DataBase Reference]
51285-26-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Synthesis]
General procedure for the synthesis of 2-amidinopyridine hydrochloride from 2-cyanopyridine: 2-cyanopyridine (26.01 g) was reacted with sodium methanol solution at room temperature with stirring for 22 h. Subsequently, ammonium chloride (28.01 g) was added and the reaction was continued for 6 h. The reaction was completed by filtration. After completion of the reaction, the unreacted ammonium chloride was removed by filtration. The filtrate was dried by rotary evaporator to remove the solvent and the resulting residue was washed with methanol to give a light yellow solid powder. It was further washed three times with ether to remove unreacted 2-cyanopyridine. Finally, recrystallization was carried out using mixed ethanol-ether solvent to give 2-amidinopyridine hydrochloride (Compound 2) as a white solid product. Yield: 83%. | [References]
[1] Patent: CN105399775, 2016, A. Location in patent: Paragraph 0026-0028
[2] Patent: CN103936795, 2016, B. Location in patent: Paragraph 0032-0035
[3] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 9, p. 2600 - 2617
[4] Patent: WO2011/130908, 2011, A1. Location in patent: Page/Page column 53
[5] Patent: WO2011/133444, 2011, A1. Location in patent: Page/Page column 52 |
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