| Identification | Back Directory | [Name]
GW 803430 | [CAS]
515141-51-2 | [Synonyms]
GW 3430
GW 803430
GW-803430A
GW-803430 >=98% (HPLC)
Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(4-chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]
6-(4-Chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one
6-(4-chloro-phenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3H-thieno[3,2-d]pyrimidin-4-one
Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(4-chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]- | [Molecular Formula]
C25H24ClN3O3S | [MDL Number]
MFCD09970889 | [MOL File]
515141-51-2.mol | [Molecular Weight]
481.99 |
| Chemical Properties | Back Directory | [Boiling point ]
677.7±65.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥4mg/mL at warmed to 60°C | [form ]
powder | [pka]
9.52±0.20(Predicted) | [color ]
white to beige | [InChI]
1S/C25H24ClN3O3S/c1-31-22-14-19(8-9-21(22)32-13-12-28-10-2-3-11-28)29-16-27-20-15-23(33-24(20)25(29)30)17-4-6-18(26)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3 | [InChIKey]
MWULMTACIBZPGN-UHFFFAOYSA-N | [SMILES]
[s]1c2c(nc[n]([c]2=O)c4cc(c(cc4)OCCN5CCCC5)OC)cc1c3ccc(cc3)Cl |
| Hazard Information | Back Directory | [Uses]
GW 803430 is a melanin-concentrating hormone receptor 1( MCH1) antagonist for treatment of obesity and depression. | [Biochem/physiol Actions]
GW-803430 antagonizes central MCHR1 and produces anxiolytic, anti-depressant and anti-obesity effects in rats and mice. It also controls the alcohol-seeking behavior in rats and is a promising treatment for alcohol use-related disorders. | [in vivo]
GW-803430 (0.3, 3, and 15 mg/kg; oral administration; once daily) causes a sustained dose-dependent weight loss relative to vehicle controls[1].
GW-803430 is a suitable compound for its good pharmacokinetic properties (bioavailability=31%, t1/2=11 h) and brain penetration (6:1 brain:plasma concentration) in mice[1]. | Animal Model: | High fat diet-induced obese AKR/J mice[1] | | Dosage: | 0.3, 3, and 15 mg/kg | | Administration: | Orally, qd,12 days | | Result: | Caused a sustained dose-dependent weight loss of -6.2%, -12.1%, and -13.1%, respectively, relative to vehicle controls. |
| [storage]
Store at -20°C |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|