| Identification | Back Directory | [Name]
4,4'-Cyclohexylidenemethylenediphenol | [CAS]
5189-40-2 | [Synonyms]
F 6060
4,4'-Cyclohexylidenemethylenediphenol
4,4'-(Cyclohexylidenemethylene)bisphenol
4,4'-DIHYDROXY BENZHYDRYLIDENE CYCLOHEXANE
Phenol, 4,4'-(cyclohexylidenemethylene)bis-
4-[Cyclohexylidene(p-hydroxyphenyl)methyl]phenol
4-[cyclohexylidene(4-hydroxyphenyl)methyl]phenol
Cyclofenildiphenol, 4,4-Cyclohexylidenemethylenediphenol | [EINECS(EC#)]
225-972-5 | [Molecular Formula]
C19H20O2 | [MDL Number]
MFCD01745689 | [MOL File]
5189-40-2.mol | [Molecular Weight]
280.36 |
| Chemical Properties | Back Directory | [Melting point ]
235-236 °C(Solv: ethanol (64-17-5); ligroine (8032-32-4)) | [Boiling point ]
462.8±25.0 °C(Predicted) | [density ]
1.180±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
9.83±0.30(Predicted) |
| Hazard Information | Back Directory | [Uses]
4,4'-(Cyclohexylidenemethylene)diphenol (Compound 2) is a symmetric cyclic nonsteroidal estrogen. 4,4'-(Cyclohexylidenemethylene)diphenol has high binding affinity for estrogen receptors ERα and ERβ[1]. | [IC 50]
ERα; ERβ | [References]
[1] Kieser KJ, et al. Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs). J Med Chem. 2010 Apr 22;53(8):3320-9. DOI:10.1021/jm100047k |
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