| Identification | Back Directory | [Name]
4-Pyrimidinecarboxamide, 1,6-dihydro-5-hydroxy-6-oxo-2-(2-thienyl)-N-[[4-(trifluoromethyl)phenyl]methyl]- | [CAS]
519021-48-8 | [Synonyms]
pUL89 Endonuclease-IN-2
4-Pyrimidinecarboxamide, 1,6-dihydro-5-hydroxy-6-oxo-2-(2-thienyl)-N-[[4-(trifluoromethyl)phenyl]methyl]- | [Molecular Formula]
C17H12F3N3O3S | [MOL File]
519021-48-8.mol | [Molecular Weight]
395.36 |
| Hazard Information | Back Directory | [Uses]
pUL89 Endonuclease-IN-2 (Compound 15k) is a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease with the IC50 of 3.0 μM. Antiviral activities[1]. | [References]
[1] Tianyu He, et al. 4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease. J Med Chem. 2022 Apr 14;65(7):5830-5849. DOI:10.1021/acs.jmedchem.2c00203 |
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