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51951-05-4

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51951-05-4 Structure

51951-05-4 Structure
IdentificationBack Directory
[Name]

HO-PEG3-CH2COOH
[CAS]

51951-05-4
[Synonyms]

51951-05-4
PEG3-O-CH2COOH
PROTAC Linker 8
HO-PEG3-CH2COOH
triethylene glycol monoglycolide
2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetic acid
Acetic acid, 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-
[Molecular Formula]

C8H16O6
[MDL Number]

MFCD24479936
[MOL File]

51951-05-4.mol
[Molecular Weight]

208.21
Chemical PropertiesBack Directory
[Boiling point ]

375.2±27.0 °C(Predicted)
[density ]

1.211±0.06 g/cm3(Predicted)
[form ]

Viscous Liquid
[pka]

3.39±0.10(Predicted)
[color ]

Colorless to light yellow
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard InformationBack Directory
[Uses]

PEG3-O-CH2COOH (PROTAC Linker 8) is a PEG-based PROTAC linker can be used in the synthesis of SNIPERs[1].
[IC 50]

PEGs
[References]

[1] Ohoka N, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). J Biol Chem. 2017 Mar 17;292(11):4556-4570. DOI:10.1074/jbc.M116.768853
Spectrum DetailBack Directory
[Spectrum Detail]

HO-PEG3-CH2COOH(51951-05-4)1HNMR
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