| Identification | Back Directory | [Name]
N,N'-bis(salicylideneamino)ethane-manganese(II) | [CAS]
53177-12-1 | [Synonyms]
EUK-8
EUK-8 >=95% (HPLC)
Manganese(salen) chloride
(Salen)manganese(III) chloride
(Salen)manganese(III) chloride (EUK-8)
N,N'-bis(salicylideneamino)ethane-manganese(II)
Chloro(bis(salicylidene)ethylenediamine)manganese
Chloro[N,N′-ethylenebis(salicylideneaminato)]manganese
N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II)
(SP-5-13)-Chloro[[2,2′-[1,2-ethanediylbis(nitrilomethylidyne)]bis[phenolato]](2-)-N,N′,O,O′]-manganese
(SP-5-13)-Chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-alphaN)methylidyne]]bis[phenolato-alphaO]](2-)]manganese
N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II)
(SP-5-13)-Chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-alphaN)methylidyne]]bis[phenolato-alphaO]](2-)]manganese | [Molecular Formula]
C16H14ClMnN2O2 | [MOL File]
53177-12-1.mol | [Molecular Weight]
356.686 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
H2O: soluble1mg/mL, clear | [form ]
powder | [color ]
faint to very dark brown | [Water Solubility ]
H2O: 1mg/mL, clear |
| Hazard Information | Back Directory | [Uses]
[N,N 0-Disalicylidene-1,2-ethanediaminato-(2-)]manganese(III) Chloride is an oxidation catalysts and an enzyme mimetic. It also functions as an intermediate in the synthesis of manganese(III) complexes with fluorinated salen derivatives that exhibits antioxidant properties. | [Biochem/physiol Actions]
EUK-8 is a salen manganese complex that exhibit potent antioxidant activities. EUK-8 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-8 disrupts the pre-formed amyloid fibrils. EUK-8 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils. | [in vivo]
Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant[3]. | Animal Model: | Wild-type (WT) and harlequin (Hq) B6CBA male and female mice[3] | | Dosage: | 25 mg/kg/day | | Administration: | I.p. 3 times a week for 4 weeks | | Result: | Prevented myocardial oxidant damage provoked by biomechanical stress.
Improved survival following biomechanical stress.
Prevented functional and geometrical deterioration in response to pressure overload.
Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis. |
| [storage]
Store at -20°C |
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