| Identification | More | [Name]
1-Acetyl-2-imidazolidinone | [CAS]
5391-39-9 | [Synonyms]
1-ACETYL-1,3,4,5-TETRAHYDROIMIDAZOLE-2-ONE
1-ACETYL-2-IMIDAZOLIDINONE
1-ACETYL-IMIDAZOLIDIN-2-ONE
ACETYL IMIDAZO-2-ONE
n-acetyl-2-imidazolidinone
RARECHEM AQ NN 0041
1-Acetyl-2-Imidazolidone
1-acetylimidazolidine-2-thione
Acetyl Ethylene Urea | [EINECS(EC#)]
226-388-3 | [Molecular Formula]
C5H8N2O2 | [MDL Number]
MFCD07783646 | [Molecular Weight]
128.13 | [MOL File]
5391-39-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
173-175°C | [density ]
1.237 | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
12.11±0.20(Predicted) | [color ]
White to Off-White | [InChI]
InChI=1S/C5H8N2O2/c1-4(8)7-3-2-6-5(7)9/h2-3H2,1H3,(H,6,9) | [InChIKey]
JJWACYUTERPMBM-UHFFFAOYSA-N | [SMILES]
C1(=O)N(C(C)=O)CCN1 | [CAS DataBase Reference]
5391-39-9(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Uses]
1-Acetyl-2-imidazolidinone (Clonidine EP Impurity A) is a synthetic reagent used in the preparation of triple [14C]-labelled moxonidine which is an antihypertensive compound. |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 1-acetyl-2-imidazolidinone from 2-imidazolidinone and acetic anhydride: 5.18 g (60.2 mmol) of 2-imidazolidinone and 50 mL of acetic anhydride were added to a 100 mL round-bottom flask. The mixture was placed in an oil bath and the reaction was stirred at 150 °C for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and filtered to collect the precipitated solid. The solid was washed with a small amount of cold ethanol to give a final 4.94 g (yield: 64.1%) of colorless solid 1-acetyl-2-imidazolidinone. | [References]
[1] Chemistry - A European Journal, 2002, vol. 8, # 11, p. 2464 - 2475
[2] Patent: JP2016/145198, 2016, A. Location in patent: Paragraph 0087-0089
[3] Arkivoc, 2014, vol. 2014, # 2, p. 44 - 56
[4] Journal of the American Chemical Society, 1958, vol. 80, p. 6409,6412 |
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