| Identification | Back Directory | [Name]
Corylin | [CAS]
53947-92-5 | [Synonyms]
Corylin
3-(2,2-dimethylchromen-6-yl)-7-hydroxychromen-4-one
7-Hydroxy-2',2'-dimethyl-2'H,4H-3,6'-bichromen-4-one
4H-1-Benzopyran-4-one, 3-(2,2-dimethyl-2H-1-benzopyran-6-yl)-7-hydroxy- | [Molecular Formula]
C20H16O4 | [MDL Number]
MFCD20260784 | [MOL File]
53947-92-5.mol | [Molecular Weight]
320.34 |
| Chemical Properties | Back Directory | [Melting point ]
238-239 °C(Solv: acetone (67-64-1); hexane (110-54-3)) | [Boiling point ]
527.4±50.0 °C(Predicted) | [density ]
1.295±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO : ≥ 100 mg/mL (312.17 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
powder | [pka]
6.98±0.20(Predicted) | [color ]
Yellowish | [InChI]
InChI=1S/C20H16O4/c1-20(2)8-7-13-9-12(3-6-17(13)24-20)16-11-23-18-10-14(21)4-5-15(18)19(16)22/h3-11,21H,1-2H3 | [InChIKey]
PWAACAMQKVIVPZ-UHFFFAOYSA-N | [SMILES]
C1OC2=CC(O)=CC=C2C(=O)C=1C1C=C2C(=CC=1)OC(C)(C)C=C2 | [CAS DataBase Reference]
53947-92-5 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Psoralea fruit. | [Uses]
Corylin has anti-inflammatory, anti-viral, anti-aging, anti-bacterial and anti-tumor effects. | [Biological Activity]
Corylin is an important biologically active compound isolated from Psoralea; antibiotic or anticancer compound. | [in vivo]
Corylin (60 mg/kg, i.p., three times a week, 4 weeks) inhibits tumor growth in Huh7 cells xenograft mice[3].
Corylin (50-100 mg/kg, p.o., daily, 9 weeks) improves the high-fat diet (HFD)-induced obesity in HFD- and DIO-treated mice[3].
| Animal Model: | HFD- and DIO-treated mice[3] | | Dosage: | 50-100 mg/kg | | Administration: | Oral gavage (p.o.), daily, 9 weeks | | Result: | Reduced the weight of subcutaneous, visceral WAT, and body.
Decreased the size of WAT adipocyte.
Increased insulin sensitivity, mitochondrial biogenesis, and β-oxidation.
Reduced serum levels of insulin and leptin and improved HOMA-IR.
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| [storage]
4°C, protect from light |
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