| Identification | Back Directory | [Name]
Benzamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, hydrochloride (1:1) | [CAS]
539857-64-2 | [Synonyms]
WF-536 Hydrochloride
Benzamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, hydrochloride (1:1) | [Molecular Formula]
C14H16ClN3O | [MDL Number]
MFCD06407678 | [MOL File]
539857-64-2.mol | [Molecular Weight]
277.75 |
| Hazard Information | Back Directory | [Description]
WF-536 Hydrochloride is a novel inhibitor of ROCK, inhibiting tumour metastasis in some animal models. | [Uses]
WF-536 is an orally active inhibitor of Rho-associated coiled-coil-containing protein kinase (ROCK). WF-536 has tumor anti-metastatic activity. WF-536 can be used for the research of cancer[1]. | [in vivo]
WF-536 (oral; 0.3-3 mg/kg/day; for 28 days) inhibits Lewis lung carcinoma (LLC) metastasis and LLC-induced angiogenesis in mice[1]. | Animal Model: | C57BL/6 mice (male, 6-week old)[1] | | Dosage: | 0.3, 1, 3 mg/kg | | Administration: | Oral; daily; for 28 days | | Result: | Significantly reduced the number of pulmonary metastatic colonies of LLC in a dose-dependent manner (0.3- 3 mg/kg). |
| [References]
[1] Nakajima, Masahide et al. Wf-536 prevents tumor metastasis by inhibiting both tumor motility and angiogenic actions. European journal of pharmacology vol. 459,2-3 (2003): 113-20. DOI:10.1016/s0014-2999(02)02869-8 |
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