| Identification | Back Directory | [Name]
2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide | [CAS]
53995-62-3 | [Synonyms]
PFI-90
N'-(Pyridin-2-yl)picolinohydrazide
2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide | [Molecular Formula]
C11H10N4O | [MDL Number]
MFCD27925103 | [MOL File]
53995-62-3.mol | [Molecular Weight]
214.22 |
| Chemical Properties | Back Directory | [Melting point ]
128-131 °C | [Boiling point ]
359.4±17.0 °C(Predicted) | [density ]
1.309±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
10.14±0.23(Predicted) | [color ]
Light yellow to yellow | [InChI]
1S/C11H10N4O/c16-11(9-5-1-3-7-12-9)15-14-10-6-2-4-8-13-10/h1-8H,(H,13,14)(H,15,16) | [InChIKey]
GCZPXNWBXDWHKM-UHFFFAOYSA-N | [SMILES]
N(NC(=O)c2ncccc2)c1ncccc1 || O=C(C1=NC=CC=C1)NNC2=NC=CC=C2 |
| Hazard Information | Back Directory | [Uses]
PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1). | [Biological Activity]
PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1).
PFI-90 shows dose response in RH4, RH30, OSA-CL and TC-32 cells, with IC50s of 812, 3200, 1895 and 1113 nM, respectively[1]. PFI-90 (3 μμ; 24 hours) increases apoptosis in RH4 and SCMC cells[1]. | [IC 50]
KDM3 | [References]
[1]. KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1. |
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