| Identification | Back Directory | [Name]
4-Quinolinecarboxamide, N,N-bis(1-methylethyl)-2-phenyl- | [CAS]
541535-31-3 | [Synonyms]
MS437
MS-437
MS 437
4-Quinolinecarboxamide, N,N-bis(1-methylethyl)-2-phenyl- | [Molecular Formula]
C22H24N2O | [MOL File]
541535-31-3.mol | [Molecular Weight]
332.44 |
| Chemical Properties | Back Directory | [Boiling point ]
518.6±38.0 °C(Predicted) | [density ]
1.093±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.19±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
MS437 is a potent agonist of the TSH receptor (TSHR). | [Uses]
MS437 is a potent TSH receptor (TSHR) stimulator with an EC50 value of 13x10-8 M. MS437 shows potent activation of Gsα, Gαq and Gα12 and up-regulation of thyroglobulin (Tg), sodium iodine symporter (NIS) and TSHR gene expressions[1]. | [References]
[1] Latif R, et al. New small molecule agonists to the thyrotropin receptor. Thyroid. 2015 Jan;25(1):51-62. DOI:10.1089/thy.2014.0119 |
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