| Identification | Back Directory | [Name]
4,4'-[[2,4,6-Trihydroxy-5-(2-methyl-1-oxopropyl)-1,3-phenylene]bis(2-methylpropane-1,1-diyl)]bis[5-hydroxy-2,2,6,6-tetramethyl-4-cyclohexene-1,3-dione] | [CAS]
54247-21-1 | [Synonyms]
Myrtucommulone
Myrtucommulone A
4,4'-[[2,4,6-Trihydroxy-5-(2-methyl-1-oxopropyl)-1,3-phenylene]bis(2-methylpropane-1,1-diyl)]bis[5-hydroxy-2,2,6,6-tetramethyl-4-cyclohexene-1,3-dione]
4-Cyclohexene-1,3-dione, 4,4'-[[2,4,6-trihydroxy-5-(2-methyl-1-oxopropyl)-1,3-phenylene]bis[(1R)-2-methylpropylidene]]bis[5-hydroxy-2,2,6,6-tetramethyl- | [Molecular Formula]
C38H52O10 | [MOL File]
54247-21-1.mol | [Molecular Weight]
668.81 |
| Chemical Properties | Back Directory | [Melting point ]
183-185 °C(Solv: methanol (67-56-1)) | [Boiling point ]
785.9±60.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [pka]
4.20±1.00(Predicted) |
| Hazard Information | Back Directory | [Description]
Myrtucommulone is an inhibitor of the chaperonin activity of HSP60, correlating to LONP and LRP130 aggregation. | [Uses]
Myrtucommulone A is a non-prenylated acylphloroglucinol that can be isolated from Myrtus communis (myrtle). Myrtucommulone A interacts with the HSP60 chaperone and inhibits HSP60 chaperone activity. Myrtucommulone A decreases the expression of LRP130, LONP[1][2]. | [References]
[1] Wiechmann K, et al. Mitochondrial Chaperonin HSP60 Is the Apoptosis-Related Target for Myrtucommulone. Cell Chem Biol. 2017 May 18;24(5):614-623.e6. DOI:10.1016/j.chembiol.2017.04.008
[2] Hans M, et al. Stereoisomeric Composition of Natural Myrtucommulone A. J Nat Prod. 2015 Oct 23;78(10):2381-9. DOI:10.1021/acs.jnatprod.5b00358 |
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