| Identification | Back Directory | [Name]
roemerine | [CAS]
548-08-3 | [Synonyms]
roemerine
(-)-Remerine
(-)-Roemarine
Remerine【alkaloid】
Roemerine【alkaloid】
(-)-N-Methylanonaine
(-)-Roemerine【alkaloid】
(6aR)-6-Methyl-1,2-(methylenedioxy)-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
[7aR,(-)]-6,7,7a,8-Tetrahydro-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline
5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7,7a,8-tetrahydro-7-methyl-, (7aR)- | [Molecular Formula]
C18H17NO2 | [MOL File]
548-08-3.mol | [Molecular Weight]
279.33 |
| Chemical Properties | Back Directory | [Melting point ]
102-103℃ | [Boiling point ]
424.0±34.0 °C(Predicted) | [density ]
1.269±0.06 g/cm3 (20 ºC 760 Torr) | [solubility ]
Chloroform: soluble | [form ]
A solid | [pka]
7.87±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Roemerine is an (-)-aporphine type of alkaloid which has been shown to possess significant antibacterial activity against Escheria Coli. | [Definition]
ChEBI: Remerin is an isoquinoline alkaloid. | [in vivo]
Roemerine (30 mg/kg, i.p., once every three days for 30 days) significantly inhibited tumor growth in the prostate cancer BALB/C nude mouse model (established by subcutaneous implantation of RM-1 cells)[2].
Roemerine (20 mg/kg, i.p., once daily for 2 days) increases survival and reduced bacterial loads in multiple organs in the MRSA XJ75302-induced sepsis BALB/C mouse model[5]. | Animal Model: | Prostate cancer BALB/C nude mouse model (established by subcutaneous implantation of RM-1 cells)[3] | | Dosage: | 30 mg/kg | | Administration: | Intraperitoneal injection (i.p.), once every three days for 30 days | | Result: | Significantly reduced tumor volume and weight in the experimental group (P < 0.05), with an inhibition rate of 41.2%. |
| Animal Model: | MRSA XJ75302-induced sepsis BALB/C mouse model[5] | | Dosage: | 20 mg/kg | | Administration: | Intraperitoneal injection (i.p.), once daily, for 2 days | | Result: | Increased the 7-day survival rate of mice to 58.3% (p < 0.05) and reduced bacterial loads in the liver (4.71 to 4.38 log CFU/mL), kidney (4.37 to 3.79 log CFU/mL), heart (5.44 to 3.76 log CFU/mL), and blood (6.52 to 4.55 log CFU/mL).
Note: CFU/mL represents the number of bacteria per milliliter of culture medium or tissue sample that can form colonies (CFU, Colony-Forming Units). |
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