| Identification | Back Directory | [Name]
PD 334581 | [CAS]
548756-68-9 | [Synonyms]
PD 334581
N-[5-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]-1,3,4-oxadiazol-2-yl]-4-morpholineethanamine | [Molecular Formula]
C20H19F3IN5O2 | [MOL File]
548756-68-9.mol | [Molecular Weight]
545.3 |
| Chemical Properties | Back Directory | [Boiling point ]
536.6±60.0 °C(Predicted) | [density ]
1.676±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 100 mM in DMSO and to 10 mM in ethanol | [form ]
Powder | [pka]
6.57±0.10(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Description]
PD 334581 is a MEK inhibitor that inhibits MEK activity in C26 colon carcinoma cells with an IC50 value of 0.032 μM. | [Uses]
PD 334581 is used in biological studies to evaluate halogen bonding as a novel interaction for rational drug design. It is also an inhibitor of MEK1. | [IC 50]
MEK1 | [storage]
Store at -20°C | [References]
[1] JOSEPH S. WARMUS . 2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)[J]. Bioorganic & Medicinal Chemistry Letters, 2008, 18 23: Pages 6171-6174. DOI: 10.1016/j.bmcl.2008.10.015 |
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| Company Name: |
BOC Sciences
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| Website: |
https://www.bocsci.com |
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