| Identification | Back Directory | [Name]
NARASIN | [CAS]
55134-13-9 | [Synonyms]
c7819b
Narasul
a28086a
monteban
narasina
Narasia A
compound79891
antibioticc7819b
Narasin (125 mg)
Monteban narasi A
antibiotica28086a
NARASIN USP/EP/BP
4-methylsalinomycin
4-methyl-salinomyci(4s)
antibiotica-28086factora
(4S)-4-Methylsalinomycin
(4S)-4β-Methylsalinomycin
Narasin Ready Made Solution
Salinomycin, 4-methyl-, (4S)-
4-MethylsalinoMycin, A28086A, C7819A
narasin from streptomyces auriofaciens | [EINECS(EC#)]
213-574-4 | [Molecular Formula]
C43H72O11 | [MDL Number]
MFCD00133653 | [MOL File]
55134-13-9.mol | [Molecular Weight]
765.03 |
| Chemical Properties | Back Directory | [Melting point ]
98-100° | [alpha ]
D25 -54° (c = 0.2 in methanol) | [Boiling point ]
842.5±65.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
methanol: soluble20mg/mL | [form ]
solution | [pka]
7.9 (80% aq DMF) | [color ]
White to off-white | [biological source]
Streptomyces aureofaciens | [InChIKey]
VHKXXVVRRDYCIK-DIHYCEDHNA-N | [SMILES]
CCC(C1OC(C(C)CC1C)C(C)C(O)C(C)C(=O)C(CC)C2OC3(OC4(CCC(C)(O4)C5CCC(O)(CC)C(C)O5)C(O)C=C3)C(C)CC2C)C(O)=O |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Danger | [Hazard statements ]
H300 | [Precautionary statements ]
P264-P301+P310 | [Hazard Codes ]
T+ | [Risk Statements ]
28 | [Safety Statements ]
28-36/37-45 | [RIDADR ]
UN 2811 6.1/PG 2
| [WGK Germany ]
3
| [RTECS ]
VO8640000
| [HazardClass ]
6.1(a) | [PackingGroup ]
II | [HS Code ]
2941906000 | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 2 Oral | [Toxicity]
LD50 i.p. in mice: 7.15 mg/kg (Berg) |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Narasin (4-methylsalinomycin) is a polyether antibiotic isolated from Streptomyces aureofaciens in 1978. Although narasin is a close analogue of salinomycin, the metabolites are produced by different species and are not co-metabolites. Narasin shows broad spectrum activity against Gram positive bacteria including anaerobes and mycoplasma, and also possesses antiviral and limited antifungal activity. Narasin is used in the animal health industry as an in-feed antibiotic and growth promotant. | [Uses]
Narasin is the main component of a polyether antibiotic complex produced by Streptomyces auriofaciens NRRL 5758 & NRRL 8092. Ionophoric antibiotic which inhibits coccidial infection in poultry and mammals.
Coccidiostat; growth stimulant. | [Definition]
ChEBI: Narasin is a diterpene glycoside. | [Brand name]
Monteban (Lilly). | [Biological Activity]
Narasin is a growth-promoting ionophoric antibacterial agent for Enterococcispecifically Enterococcus faecium and Enterococcus faecalis. Narasin inhibits coccidial infection in poultry and mammals and is used in studies involving sodium calcium ion exchange.
In additionNarasin inhibits Dengue virus (DENV) at the post-entry stage of viral replication during DENV infection. The inhibition of DENV involves a non-cytotoxic mechanismthereforeNarasin can be possibly considered as therapeutic agent against DENV infection. A dose dependent curve (0.01-5 μM) showed th at Narasin has 50% inhibitory concentration at less than 1 μM against all four serotypes of DENV. The IC50 (μM) of Narasin against four different DENV serotypes was 0.05-0.65 μM. |
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