| Identification | Back Directory | [Name]
TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01) | [CAS]
552309-42-9 | [Synonyms]
T16Ainh-A01
TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem
TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01)
2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide
Acetamide, 2-[(5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]- | [Molecular Formula]
C19H20N4O3S2 | [MDL Number]
MFCD03278952 | [MOL File]
552309-42-9.mol | [Molecular Weight]
416.52 |
| Chemical Properties | Back Directory | [Melting point ]
211-212°C (dec.) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [pka]
7.20±0.50(Predicted) | [color ]
white to beige | [InChI]
1S/C19H20N4O3S2/c1-4-14-11(2)20-18(23-17(14)25)28-10-16(24)22-19-21-15(9-27-19)12-5-7-13(26-3)8-6-12/h5-9H,4,10H2,1-3H3,(H,20,23,25)(H,21,22,24) | [InChIKey]
QSIYTNYMBWYHAA-UHFFFAOYSA-N | [SMILES]
CCc1c(C)nc(SCC(=O)Nc2nc(cs2)-c3ccc(OC)cc3)nc1O |
| Hazard Information | Back Directory | [Uses]
TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01) compound functions as a selective class A inhibitor of the calcium activated chloride channel TMEM16A. Useful in the treatment of hypertension, pain, diarrhea and mucus overproduction.
| [General Description]
An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 μM). Fully blocks CaCC current in salivary gland cells at 10 μM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No. 631547) at 10 μM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels. | [Biochem/physiol Actions]
T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current. T16Ainh-A01 does not alter cytoplasmic calcium and has little effect on CFTR Cl- conductance. | [storage]
Store at -20°C |
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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