5527-95-7

The reaction was carried out in an 80 mL Teflon-lined stainless steel reactor equipped with a magnetic stir bar. 4-Chloro-3-fluoroiodobenzene (1.0 mmol), rhodium(III) chloride hydrate (0.025 mmol), PPh3 (0.1 mmol), Et3N (1.2 mmol), and N,N-dimethylacetamide (2 mL) were added to the reactor in a glove box. The autoclave was tightened. CO and H2 were injected into the autoclave to bring the total pressure to 10 bar (1:1). The mixture was transferred to an oil bath preheated at 90°C for 12 hours. The reaction was controlled using a Haake-D3 temperature controller. After the reaction was complete, the reactor was cooled in ice water. The atmosphere was carefully vented.