| Identification | More | [Name]
3-METHYLTHIOPHENE-2-CARBONITRILE | [CAS]
55406-13-8 | [Synonyms]
2-CYANO-3-METHYLTHIOPHENE
3-METHYLTHIOPHENE-2-CARBONITRILE
3-Methyl-2-thiophenecarbonitrile
3-Methylthiophene-2-carbonitrile 98% | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C6H5NS | [MDL Number]
MFCD00052086 | [Molecular Weight]
123.18 | [MOL File]
55406-13-8.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
3276 | [Hazard Note ]
Irritant | [HazardClass ]
6.1 | [PackingGroup ]
III |
| Hazard Information | Back Directory | [Preparation]
3-Methylthiophene-2-carbonitrile synthesis: 3-Methyl-2-thiophenecarboxamide (18.6 g, 0.13 mol) was mixed with an excess of POCl3, and the mixture heated at reflux temperature for 2 h. The excess POCl3 was removed under vacuum and the residue dissolved in 500 mL of 1,2-dichloroethane, washed (carefully!) with water, then brine, and the solvent removed to give 23 g of crude 3-methyl-2-thiophenecarbonitrile. This material was passed through a plug of silica gel with CH2Cl2 and the solvent evaporated to give 16.2 g (100%) of as a light tan oil: 1H NMR (CDCl3) d 7.4 (d, J=4.8 Hz, 1H), 6.9 (d, J=5.4 Hz, 1H), 2.4 ppm (s, 3H); 97% pure by HPLC area %. |
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