| Identification | More | [Name]
2,4-DIMETHYLPHENYLBORONIC ACID | [CAS]
55499-44-0 | [Synonyms]
2,4-DIMETHYLBENZENEBORONIC ACID
2,4-DIMETHYLPHENYLBORONIC ACID
AKOS BRN-0225
M-XYLENE-4-BORONIC ACID
2,4-Dimethylphenylboronic
2,4-Dimethylphenylboronic Acid (contains varying amounts of Anhydride) | [Molecular Formula]
C8H11BO2 | [MDL Number]
MFCD02683101 | [Molecular Weight]
149.98 | [MOL File]
55499-44-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
204-208°C | [Boiling point ]
292.4±50.0 °C(Predicted) | [density ]
1.07±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [Water Solubility ]
Slightly soluble in water | [form ]
powder to crystal | [pka]
8.92±0.58(Predicted) | [color ]
White to Light yellow | [CAS DataBase Reference]
55499-44-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36/37:Wear suitable protective clothing and gloves . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29319090 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
suzuki reaction | [Synthesis]
The general procedure for the synthesis of 2,4-dimethylphenylboronic acid from triisopropyl borate and 2,4-dimethylbromobenzene was as follows: 3.42 g (0.140 mol) of magnesium and 9 mL of tetrahydrofuran were added to a reaction vessel fitted with a dropping funnel under nitrogen protection. Subsequently, a solution consisting of 20.0 g (0.108 mol) of 2,4-dimethylbromobenzene dissolved in 60 mL of tetrahydrofuran (Eq. I-4-1) was added dropwise to prepare the Grignard reagent. After the reaction mixture was stirred for 2 hours, 14.6 g (0.140 mol) of trimethyl borate was added slowly and dropwise. After continued stirring for 2 hours, hydrochloric acid was added and stirred for 1 hour. Upon completion of the reaction, the organic layer was separated, washed with brine, and then the solvent was removed by distillation to afford 15.4 g (0.103 mol) of 2,4-dimethylphenylboronic acid (Formula I-4-2). | [References]
[1] Patent: JP2015/110532, 2015, A. Location in patent: Paragraph 0132-0133 |
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