| Identification | Back Directory | [Name]
deltonin | [CAS]
55659-75-1 | [Synonyms]
deltonin
3-O-beta-D-Glucopyranosyl(1-4)-[alpha-L-rhamnopyranosyl(1-2)]-beta-D-glucopyranoside-diosgenin
Deltonin,3-O-β-D-Glucopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside-diosgenin
β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]- | [Molecular Formula]
C45H72O17 | [MDL Number]
MFCD26145166 | [MOL File]
55659-75-1.mol | [Molecular Weight]
885.04 |
| Chemical Properties | Back Directory | [Melting point ]
298-300 °C (decomp) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [form ]
Solid | [pka]
12?+-.0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis, has antitumor activity; Deltonin inhibits ERK1/2 and AKT activation. | [Definition]
ChEBI: Deltonin is a triterpenoid. | [in vivo]
Deltonin (20 and 40 mg/kg, p.o.) reduces the tumor growth of 37.7% and 56.7%, and causes a 50-day survival rate of 60% and 50%, respectively, in mice. Deltonin also inhibits tumor angiogenesis in mice[1]. | [IC 50]
ERK1; ERK2; Akt | [References]
[1] Tong QY, et al. Deltonin, a steroidal saponin, inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and antiangiogenesis. Cell Physiol Biochem. 2011;27(3-4):233-42. DOI:10.1159/000327949
[2] Zhang S, et al. Deltonin induces apoptosis in MDA?MB?231 human breast cancer cells via reactive oxygen species?mediated mitochondrial dysfunction and ERK/AKT signaling pathways. Mol Med Rep. 2013 Mar;7(3):1038-44. DOI:10.3892/mmr.2013.1273 |
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