55659-75-1
55659-75-1 结构式
基本信息
三角叶薯蓣皂甙
三角叶薯蓣皂苷对照品
三角叶薯蓣皂苷标准品
3-O-beta-D-Glucopyranosyl(1-4)-[alpha-L-rhamnopyranosyl(1-2)]-beta-D-glucopyranoside-diosgenin
Deltonin,3-O-β-D-Glucopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside-diosgenin
β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-
物理化学性质
常见问题列表
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ERK1
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ERK2
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Akt
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Human Endogenous Metabolite
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Deltonin inhibits ERK1/2 and AKT activation. Deltonin (0.5-8 μM) significantly inhibits the proliferation of several colon cancer cell lines including SW480, SW620, LOVO and C26, with IC 50 s of 1.3, 1.29, 2.11 and 1.22 μM. Deltonin also causes G2-M phase arrest and induces apoptosis in C26 cells. Deltonin (0-5 μM) decreases the phosphorylation of AKT and ERK1/2 levels in MDA‑MB‑231 cells. Deltonin (0.5-8 μM) also dose-dependently inhibits the proliferation, and causes apoptosis with ROS production in MDA‑MB‑231 cells.
Deltonin (20 and 40 mg/kg, p.o.) reduces the tumor growth of 37.7% and 56.7%, and causes a 50-day survival rate of 60% and 50%, respectively, in mice. Deltonin also inhibits tumor angiogenesis in mice.