| Identification | Back Directory | [Name]
Polyphyllin VI | [CAS]
55916-51-3 | [Synonyms]
Paris VI
Saponin Tb
Polyhyllin VI
Polyphyllin Ⅵ
Polyphyllin VI
product/154909
Paris saponin VI
17-Hydroxyparis V
Chonglou saponin Ⅵ
Polyphyllin F (Formosanin VI)
Polyphyllin F (Polyphyllin VI)
b-D-Glucopyranoside, (3b,25R)-17-hydroxyspirost-5-en-3-yl2-O-(6-deoxy-a-L-mannopyranosyl)-
β-D-Glucopyranoside, (3β,25R)-17-hydroxyspirost-5-en-3-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-
(2R,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((2'R,4S,5'R,6aR,6bS,8aS,8bS,9S,11aS,12 | [Molecular Formula]
C39H62O13 | [MDL Number]
MFCD13195303 | [MOL File]
55916-51-3.mol | [Molecular Weight]
738.9 |
| Chemical Properties | Back Directory | [Melting point ]
216-220°C | [Boiling point ]
871.2±65.0 °C(Predicted) | [density ]
1.38 | [storage temp. ]
Hygroscopic, Refrigerator, under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
12.85±0.70(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
Polyhyllin VI is a natural saponin extracted from the plant, Rhizoma Paridis, and displays anti-proliferative activity in vivo. Used in the treatment of HepG2 cells for tumor mitigation. | [in vivo]
Polyphyllin VI (2-4 mg/kg; i.p.; five times a week for 4 weeks) inhibits the growth of lung cancer tumor xenografts[1].
Polyphyllin VI (2.5-10 mg/kg; i.p.; 10 consecutive days) activates NLRP3 inflammasome in A549-bearing athymic nude mice[3].
| Animal Model: | A549 tumor xenografts subcutaneously inoculated into the right flank of the nude mice[1] | | Dosage: | 2 mg/kg, 3 mg/kg, 4 mg/kg | | Administration: | Intraperitoneal Injection (i.p.) | | Result: | Resulted the reduction of tumor volume to 25.63%, 41.71%, and 40.41%, respectively, after 2 mg/kg, 3 mg/kg and 4 mg/kg treatment. |
| Animal Model: | A549 tumor xenografts subcutaneously inoculated into the right flank of the nude mice[3] | | Dosage: | 2.5 mg/kg, 5 mg/kg, 10 mg/kg | | Administration: | Intraperitoneal Injection (i.p.) | | Result: | Showed the expression of NLRP3, caspase-1, IL-1β and GSDMD was increasing in a dose manner. |
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