| Identification | More | [Name]
CASTICIN | [CAS]
479-91-4 | [Synonyms]
3',5-DIHYDROXY-3,4',6,7-TETRAMETHOXY FLAVONE
5,3'-DIHYDROXY-3,6,7,4'-TETRAMETHOXYFLAVONE
CASTICIN
VITEXICARPIM
VITEXICARPIN
Casticin (Vitexicarpin)
CASTICIN(P)
CASTICIN WITH HPLC
(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxy-
4H-1-Benzopyran-4-one,5-hydroxy-2-
3,4',6,7-Tetramethoxy-3',5-dihydroxyflavone
5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxychromen-4-one | [Molecular Formula]
C19H18O8 | [MDL Number]
MFCD00210481 | [Molecular Weight]
374.34 | [MOL File]
479-91-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
186-187 °C | [Boiling point ]
617.7±55.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
ethanol: soluble1mg/mL, clear, colorless to light yellow | [form ]
neat | [pka]
6.13±0.40(Predicted) | [color ]
Yellow | [BRN ]
1300392 | [Major Application]
pharmaceutical (small molecule) | [InChI]
InChI=1S/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3 | [InChIKey]
PJQLSMYMOKWUJG-UHFFFAOYSA-N | [SMILES]
C1(C2=CC=C(OC)C(O)=C2)OC2=CC(OC)=C(OC)C(O)=C2C(=O)C=1OC | [CAS DataBase Reference]
479-91-4(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Soluble in a mixed solvent of DMSO, chloroform and methanol, insoluble in petroleum ether and chloroform. Derived from the Umbelliferae plant Foeniculum vulgare | [Uses]
Casticin is a biological compound known to induce human glioma cell death through an apoptotic mechanism and disruption of the mitotic cycle. | [Definition]
ChEBI: A tetramethoxyflavone that consists of quercetagetin in which the hydroxy groups at positions 3, 6, 7 and 4' have been replaced by methoxy groups. It has been isolated from Eremophila mitchellii. | [in vivo]
Casticin (20 mg/kg, p.o.) has toxic effect on the liver in mice with CCl4-and BDL-induced hepatic injury. Casticin attenuates liver fibrosis induced by CCl4 or BDL in vivo. Casticin inhibits HSC activation and collagen matrix expression by blocking TGF-β/Smad signaling in vivo[2]. |
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