| Identification | Back Directory | [Name]
5-O-methylembelin | [CAS]
56005-10-8 | [Synonyms]
5-O-methylembelin
2-hydroxy-5-methoxy-3-undecylcyclohexa-2,5-diene-1,4-dione
2,5-Cyclohexadiene-1,4-dione, 2-hydroxy-5-methoxy-3-undecyl- | [Molecular Formula]
C18H28O4 | [MOL File]
56005-10-8.mol | [Molecular Weight]
308.41 |
| Chemical Properties | Back Directory | [Melting point ]
88-90 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
439.5±45.0 °C(Predicted) | [density ]
1.06±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
2.95±0.50(Predicted) | [color ]
Light yellow to yellow | [LogP]
5.940 (est) |
| Hazard Information | Back Directory | [Uses]
5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, inducible degrader of the low-density lipoprotein receptor (IDLR), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression[1]. | [Definition]
ChEBI: A member of the class of monohydroxy-1,4-benzoquinones that is embelin in which the hydroxy group at position 5 is replaced by a methoxy group. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antileishmanial activ
ty as well as inhibitory activity towards hepatitis C protease. | [References]
[1] Pisey Pel, et al. Isocoumarins and Benzoquinones with Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activities from Dried Roots of Lysimachia vulgaris. ACS Omega. 2022 Dec 8;7(50):47296-47305. DOI:10.1021/acsomega.2c06660 |
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