| Identification | Back Directory | [Name]
[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]hydrazine | [CAS]
56173-05-8 | [Synonyms]
PCAF-IN-2
[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]hydrazine | [Molecular Formula]
C10H7F3N6 | [MOL File]
56173-05-8.mol | [Molecular Weight]
268.198 |
| Hazard Information | Back Directory | [Uses]
PCAF-IN-2 (compound 17) is a potent PCAF inhibitor with an IC50 value of 5.31 μM. PCAF-IN-2 shows anti-tumour activity. CAF-IN-2 induces apoptosis and arrest the cell cycle at the G2/M phase[1]. | [IC 50]
PCAF: 5.31 μM (IC50) | [References]
[1] Turky A, et al. Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosis-inductive and PCAF-inhibitory effects. Bioorg Chem. 2020 Aug;101:104019. DOI:10.1016/j.bioorg.2020.104019 |
|
|