| Identification | Back Directory | [Name]
methyl (19alpha,20alpha)-16,17-didehydro-10,11-dimethoxy-19-methyloxayohimban-16-carboxylate | [CAS]
572-67-8 | [Synonyms]
Isoreserpilin
3-Isoreserpiline
Einecs 209-342-7
methyl (19alpha,20alpha)-16,17-didehydro-10,11-dimethoxy-19-methyloxayohimban-16-carboxylate
(20α)-16,17-Didehydro-10,11-dimethoxy-19α-methyl-18-oxayohimban-16-carboxylic acid methyl ester
Oxayohimban-16-carboxylic acid, 16,17-didehydro-10,11-dimethoxy-19-methyl-, methyl ester, (19alpha,20alpha)- | [EINECS(EC#)]
209-342-7 | [Molecular Formula]
C23H28N2O5 | [MOL File]
572-67-8.mol | [Molecular Weight]
412.479 |
| Chemical Properties | Back Directory | [Melting point ]
211-212 °C (sublm)(Solv: ethyl ether (60-29-7)) | [Boiling point ]
569.9±50.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble | [form ]
A solid | [pka]
17.95±0.60(Predicted) |
| Hazard Information | Back Directory | [Uses]
Isoreserpiline is an orally active and BBB-penatrable indole alkaloids with antibacterial and antipsychotic activity. Isoreserpiline is even more effective when used in combination with antibiotics and inhibits the activity of bacterial efflux pumps. Isoreserpiline improves Amphetamine-induced hyperactivity in mice[1][2] . | [storage]
-20°C | [References]
[1] Dwivedi GR, et al. Synergy Potential of Indole Alkaloids and Its Derivative against Drug-resistant Escherichia coli. Chem Biol Drug Des. 2015 Dec;86(6):1471-81. DOI:10.1111/cbdd.12613
[2] Gupta S, et al. Bioactivity guided isolation of antipsychotic constituents from the leaves of Rauwolfia tetraphylla L. Fitoterapia. 2012 Sep;83(6):1092-9. DOI:10.1016/j.fitote.2012.04.029 |
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