| Identification | Back Directory | [Name]
CROTONYLOXYMETHYL-4,5,6-TRIHYDRO-OXYCYCLOHEX-2-ENONE | [CAS]
57449-30-6 | [Synonyms]
CROTONYLOXYMETHYL-4,5,6-TRIHYDRO-OXYCYCLOHEX-2-ENONE
2-Butenoic acid, [(3R,4R,5R)-3,4,5-trihydroxy-6-oxo-1-cyclohexen-1-yl]methyl ester | [Molecular Formula]
C11H14O6 | [MOL File]
57449-30-6.mol | [Molecular Weight]
242.23 |
| Chemical Properties | Back Directory | [Melting point ]
181°C | [Boiling point ]
345.05°C (rough estimate) | [density ]
1.3367 (rough estimate) | [refractive index ]
1.6000 (estimate) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble,Methanol: soluble, | [form ]
A solid | [Water Solubility ]
Water: soluble |
| Hazard Information | Back Directory | [Uses]
COTC is a bacterial metabolite with anticancer activity that is found in S. griseosporeus. COTC inhibits glyoxalase in the presence of glutathione (GSH). COTC also inhibits the proliferation of HeLa cells (IC50 = 18 μg/mL), as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model[1]. | [storage]
-20°C | [References]
[1] Takeuchi T, et al. A glyoxalase I inhibitor of a new structural type produced by Streptomyces. J Antibiot (Tokyo). 1975 Oct;28(10):737-42. DOI:10.7164/antibiotics.28.737 |
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