| Identification | Back Directory | [Name]
2(1H)-Pyridinone, 1-hydroxy-6-[1-(3-methoxypropyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-4-phenyl- | [CAS]
1415388-25-8 | [Synonyms]
Glyoxalase I inhibitor 3
2(1H)-Pyridinone, 1-hydroxy-6-[1-(3-methoxypropyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-4-phenyl- | [Molecular Formula]
C22H21N3O3 | [MOL File]
1415388-25-8.mol | [Molecular Weight]
375.42 |
| Chemical Properties | Back Directory | [Boiling point ]
622.3±65.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.97±0.58(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Glyoxalase I inhibitor 3 (compound 22g) is a potent glyoxalase I (GLO1) inhibitor with an IC50 of 0.011 μM. Glyoxalase I inhibitor 3 has the potential for the research of depression and anxiety[1]. | [References]
[1] Jin T, Zhao L, et al. Recent advances in the discovery and development of glyoxalase I inhibitors. Bioorg Med Chem. 2020 Feb 15;28(4):115243. DOI:10.1016/j.bmc.2019.115243 |
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