| Identification | Back Directory | [Name]
FENOBAM | [CAS]
57653-26-6 | [Synonyms]
FENOBAM
Mcn-3377
1-(3-Chlorophenyl)-3-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea
N-(3-CHLOROPHENYL)-N'-(4,5-DIHYDRO-1-METHYL-4-OXO-1H-IMIDAZOL-2-YL)UREA
N-(3-CHLOROPHENYL)-N'-(4,5-DIHYDRO-1-METHYL-4-OXO-1H-IMIDAZOLE-2-YL)UREA
Urea, N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)- | [Molecular Formula]
C11H11ClN4O2 | [MDL Number]
MFCD00868019 | [MOL File]
57653-26-6.mol | [Molecular Weight]
266.68 |
| Chemical Properties | Back Directory | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO: >20mg/mL | [form ]
solid | [pka]
8.32±0.20(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
Sedative-hypnotic. | [Biological Activity]
Primary Target
mGlu6 receptors''Target Ki: 54 nM and 31 nM at recombinant mGlu6 receptors of r at and humanrespectively | [in vivo]
Fenobam (30-60 mg/kg; p.o.; 3 times a week) significantly inhibits self-administration behavior in rats[3]. | Animal Model: | Male Long-Evans rats (250-300 g)[3]. | | Dosage: | 30-60 mg/kg | | Administration: | Oral administration; 3 times a week. | | Result: | Inhibited self-administration.
|
| [IC 50]
mGluR5: 84 nM (IC50); rat mGluR5: 54 nM (Kd); human mGluR5: 31 nM (Kd) | [storage]
Store at RT |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
|