| Identification | Back Directory | [Name]
3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE | [CAS]
329205-68-7 | [Synonyms]
MTEP
MTEP hydrochloride >=98% (HPLC)
2-methyl-4-(pyridin-3-ylethynyl)thiazole
3-(2-Methyl-thiazol-4-ylethynyl)-pyridine
Pyridine, 3-[(2-methyl-4-thiazolyl)ethynyl]-
3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE
2-methyl-4-(2-pyridin-3-ylethynyl)-1,3-thiazole
3-[2-(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine | [Molecular Formula]
C11H8N2S | [MDL Number]
MFCD05260891 | [MOL File]
329205-68-7.mol | [Molecular Weight]
200.26 |
| Chemical Properties | Back Directory | [Boiling point ]
360.7±17.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
methanol: 1mg/mL
DMSO: 5mg/mL | [form ]
White to yellow solid. | [pka]
3.41±0.12(Predicted) | [color ]
white to yellow | [InChI]
1S/C11H8N2S/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10/h2-3,6-8H,1H3 | [InChIKey]
NRBNGHCYDWUVLC-UHFFFAOYSA-N | [SMILES]
[s]1c(nc(c1)C#Cc2cnccc2)C |
| Hazard Information | Back Directory | [Uses]
MTEP Hydrochloride is a potent mGlu5 receptor antagonist, acting as a negative allosteric modulator. | [Biological Activity]
Cell permeable: yes''Primary Target
mGluR5''Product does not compete with ATP.''Reversible: no''Target IC50: 5 nM in Ca2+-flux assay''Target Ki: 16 nM for mGluR5 (metabotropic glutamate receptor subtype-5) | [in vivo]
MTEP (0-5 mg/kg, i.p., once) inhibits the catalepsy induced by Haloperidol (HY-14538) (0.5 mg/kg/2 ml i.p.)[2].
MTEP (0.3-3 mg/kg, intraperitoneal injection, once) induces antidepressant-like effects in male C57BL/6J mice[3]. | Animal Model: | Male Wistar rats (215-315 g, 5-9/group)[2] | | Dosage: | 1, 3 and 5 mg/kg | | Administration: | IP, once, injected 60 min after Haloperidol (HY-14538) (0.5 mg/kg/2 ml i.p.) | | Result: | Inhibited the catalepsy induced by Haloperidol (HY-14538). |
| Animal Model: | Male C57BL/6J mice (23-25 g)[3] | | Dosage: | 0.3, 1 and 3 mg/kg | | Administration: | IP, 1 h before the test | | Result: | Significantly decreased the immobility time of mice in the tail suspension test (TST) by 24%, 41% and 48%, respectively. The efficacy of MTEP used at doses of 1 and 3 mg/kg was not significantly different from that of Imipramine (HY-B1490A) (20 mg/kg, ip), used as a positive standard. |
| [IC 50]
mGluR5: 5 nM (IC50); mGluR5: 16 nM (Ki) |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
|