| Identification | Back Directory | [Name]
orvepitant | [CAS]
579475-18-6 | [Synonyms]
orvepitan
Orvepitat
orvepitant
(2R,4S)-N-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethyl)-2-(4-fluoro-2-methylphenyl)-N-methyl-4
1-Piperidinecarboxamide, N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-4-[(8aS)-hexahydro-6-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-methyl-, (2R,4S)- | [Molecular Formula]
C31H35F7N4O2 | [MOL File]
579475-18-6.mol | [Molecular Weight]
628.62 |
| Hazard Information | Back Directory | [Uses]
Orvepitant (GW823296) is a compound with the ability to inhibit pruritus induced by cancer epidermal growth factor receptor inhibitor (EGFRI) and is a neurokinin-1 receptor antagonist. | [References]
[1] Neurokinin-1 antagonist orvepitant for EGFRI-induced pruritus in patients with cancer: a randomised, placebo-controlled phase II trial DOI:10.1136/bmjopen-2019-030114 |
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