| Identification | Back Directory | [Name]
kakkalide | [CAS]
58274-56-9 | [Synonyms]
kakkalide
kakkalide USP/EP/BP
Kakkalide,Inhibitor,inhibit
4H-1-Benzopyran-4-one, 5-hydroxy-6-methoxy-3-(4-methoxyphenyl)-7-[(6-O-β-D-xylopyranosyl-β-D-glucopyranosyl)oxy]-
5-Hydroxy-6-methoxy-3-(4-methoxyphenyl)-7-[(6-O-beta-D-xylopyranosyl-beta-D-glucopyranosyl)oxy]-4H-1-benzopyran-4-one
5-Hydroxy-6-methoxy-3-(4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one | [Molecular Formula]
C28H32O15 | [MDL Number]
MFCD09970384 | [MOL File]
58274-56-9.mol | [Molecular Weight]
608.546 |
| Chemical Properties | Back Directory | [Melting point ]
250-252 °C | [Boiling point ]
902.0±65.0 °C(Predicted) | [density ]
1?+-.0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
6.08±0.20(Predicted) | [color ]
White to off-white | [LogP]
-0.292 (est) |
| Hazard Information | Back Directory | [Uses]
Kakkalide is an isoflavone derived from the flowers of Pueraria lobata. Kakkalide ameliorates endothelial insulin resistance by suppressing reactive oxygen species (ROS)-associated inflammation[1]. | [Synthesis]
Kudzu flowers were crushed and weighed 300g, respectively, extracted with 900 mL of methanol in cold soak for three times, and the combined extracts were concentrated under reduced pressure. The methanol extract was suspended in appropriate amount of dist | [References]
[1] Zhang D, et al. Kakkalide ameliorates endothelial insulin resistance by suppressing reactive oxygen species-associated inflammation. J Diabetes. 2013 Mar;5(1):13-24. DOI:10.1111/1753-0407.12017 |
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