| Identification | Back Directory | [Name]
EC-17 | [CAS]
583037-91-6 | [Synonyms]
EC-17
Folate-FTIC
FTIC-Folate
EC-17 free acid
LMEBZGHLPGBLSU-PMERELPUSA-N
L-Glutamine, N2-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-N-[2-[[[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)amino]thioxomethyl]amino]ethyl]- | [Molecular Formula]
C42H36N10O10S | [MDL Number]
MFCD25976615 | [MOL File]
583037-91-6.mol | [Molecular Weight]
872.86 |
| Hazard Information | Back Directory | [Uses]
Folate-FITC (EC-17) is a folic acid derivative that binds to fluorescein isothiocyanate (FITC) to give it fluorescent labeling properties. Folate-fitc is used to induce the formation of pseudo-immunological synapses between anti-FITC CAR T cells and target cells expressing Folate receptors (FRα or FRβ). Folate-FITC can be used to develop controlled CAR-T cell therapies for research in non-small cell lung cancer (NSCLC)[1]. | [References]
[1] Chu W, et al. Bi-specific ligand-controlled chimeric antigen receptor T-cell therapy for non-small cell lung cancer[J]. BioScience trends, 2018, 12(3): 298-308. DOI:10.5582/bst.2018.01048 |
|
| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Tel: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15748/0_EN.htm |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
|